Joanne’s life sciences experience spans research, business and operations. She helped formulate the initial scientific strategy for Jnana and has led the business and operations of the company since its launch in 2017. Prior to Jnana, she had a leadership role at FBRI, F Prime Capital’s initiative to enable therapeutic breakthroughs in Alzheimer’s disease and related brain disorders by funding innovative academic research and launching companies. Before F-Prime, Joanne was a director at the Broad Institute, where her research and business responsibilities included defining strategy and leading efforts in early stage drug discovery through collaborations with patients, disease foundations and biopharma. Joanne received her Ph.D. in chemistry from the University of California, Berkeley, and a B.S. in chemistry and B.A. in sociology from the University of Florida. She conducted postdoctoral research at the Necker Children’s Hospital in Paris and at Genentech. Following Genentech, she was at Nature Publishing Group, including as founding editor of the journal Nature Chemical Biology.
Joel came to Jnana from Achillion Pharmaceuticals, where he served as their chief scientific officer. Most of Joel’s career was spent as a medicinal chemist in pharma, where he capped a 28-year career at Bristol-Myers Squibb by spending the last five years as vice president and head of discovery chemistry, working across all therapeutic areas. In that role, Joel worked with teams responsible for advancing more than 40 compounds into clinical development, including Sprycel (dasatinib), which he co-invented. While at BMS, Joel and his colleagues made notable advances in the area of kinase inhibitor drug discovery, particularly in immunology and oncology. He is a co-author on over 130 peer reviewed publications and is a co-inventor on 40 issued U.S. patents. Prior to moving to BMS, he spent five years at Hoffmann La-Roche as a research scientist. Joel received his doctorate in organic chemistry from Columbia University and his bachelor’s in chemistry from the University of Pennsylvania.
Caroline came to Jnana from Alnylam Pharmaceuticals, where she spent eleven years in roles of increasing responsibility, and ultimately was Vice President and Head of Business Development. In that role, Caroline led the team responsible for the full range of business development activities including opportunity identification, diligence and transaction negotiations. These efforts resulted in the formation of multiple significant partnerships and licensing deals. Prior to Alnylam, Caroline was in business development at Amicus Therapeutics and started her career at Bain & Company. Caroline received her MBA from the MIT Sloan School of Management and bachelor’s in economics from Duke University.
Doug brings over two decades of experience in finance, investor relations, strategy and capital formation in the biopharmaceutical industry to Jnana. Doug has had finance and operational leadership roles in both public and venture-backed companies going through transitions from pre-clinical to clinical to commercialization. Prior to joining Jnana, he most recently served as the Chief Financial Officer of Dicerna Pharmaceuticals, where he oversaw the IT and Finance organizations and oversaw the sale of the company to Novo Nordisk for $3.3BN. Doug also served as Chief Financial Officer at KSQ Therapeutics and Paratek Pharmaceuticals, as well as Vice President of Finance at Acceleron Pharma, shepherding their IPO. Additionally, he served on the Board of Directors at Ziopharm Oncology, and held roles of increasing responsibility at Biogen, Bristol-Myers Squibb, Johnson & Johnson and JPMorgan earlier in his career. Doug earned his MBA in Finance & Accounting from Columbia Business School and a B.S.E. in Chemical Engineering with a concentration in Engineering Biology from Princeton University.
Nick is an experienced drug discovery and development leader with 20 years of experience and a proven track-record of therapeutic innovation across multiple disease areas. Before joining Jnana, he was Vice President, Integrative Sciences, Inflammation & Immunology, Cardiovascular & Fibrosis, at Bristol-Meyers Squibb and prior to this, he served as Executive Director, Inflammation & Immunology for Celgene. In both of these roles, Nick was responsible for scientific and strategic leadership of drug discovery programs applying novel technologies and scientific insights to the expansion of the Inflammation & Immunology portfolio as well as more broadly. Dr. Pullen brings extensive experience in Inflammation & Fibrosis, following a career at Pfizer which spanned more than 15 years and brought multiple development candidates to clinical evaluation and touched many disease areas including renal disease, IBD, and NASH. He received his Ph.D. in biochemistry from the University of Southampton in the UK.
Dean has over 20 years of drug discovery experience at AstraZeneca (AZ) where he held the position most recently of Director of Chemistry. Dean has been responsible for building many new drug discovery programs in both neuroscience and infection, several which have resulted in successful transition to clinical trials. Dean is a globally recognized leader in medicinal chemistry, lead generation, library design, DNA-encoded library screening, and applications of computational chemistry. He has also been responsible for leading multiple industrial-academic collaborations which resulted in successful external grants in neurodegenerative disease research. Dean is listed as an author or co-author on more than 60 publications and patent applications in medicinal chemistry and drug design, including granted patents on clinical candidates. He obtained a B.S. in chemistry at Abilene Christian University and a Ph.D. at the University of Minnesota in synthetic organic chemistry.
Dr. Throup joins Jnana from Bristol Myers Squibb (BMS) where he was most recently Vice President and Development Lead responsible for leading the development of assets in the Immunology pipeline across early and late development. Most recently, Dr. Throup led the development of the TYK2 inhibitor, deucravacitinib, from preclinical to NDA and MAA submission. Before joining BMS in 2014, Dr. Throup spent 15 years at GlaxoSmithKline (GSK) in operational and strategic leadership roles across the R&D organization. Dr. Throup received his Ph.D. in molecular microbiology from the University of Nottingham, UK.
Heather brings over 18 years of drug discovery experience to Jnana working in pharma and biotech on pre-clinical and clinical development programs. Prior to Jnana, Heather served as director of Drug Metabolism and Pharmacokinetics at Nimbus Therapeutics focusing on immunology, oncology and metabolic disease. She was a member of the clinical group working on Nimbus’ allosteric ACC inhibitor for NASH, as well as the preclinical team advancing their TYK2 allosteric inhibitor and STING discovery programs. Prior to Nimbus, Heather led the DMPK group at Cubist Pharmaceuticals, a position in which she served from 2010 until the company’s acquisition by Merck in 2015. In her time at Cubist, Heather’s work focused on acute care therapies for pain and antibiotics developed for the treatment of gram-negative and gram-positive bacteria, including the clinical development of programs including Cubicin, and Zerbaxa and more. Heather received her bachelor’s in chemistry from the University of New Hampshire and doctorate in synthetic organic chemistry from the University of Oregon prior to joining the pharmaceutical industry.
Brian is an expert finance leader with more than 20 years of global experience with fast-growing biotechnology companies. He joins Jnana from Momenta Pharmaceuticals where he led Financial Planning & Analysis. Previously, he served for more than 20 years in roles of increasing responsibility at Sanofi Genzyme. His most recent position at Sanofi Genzyme was Head of Finance for North America Rare Disease and Rare Blood Disorders, and he drove all aspects of strategic financial planning and operations for the North American region for two business units representing $2B in combined sales with over 500 employees and 12 products. In his roles at Sanofi Genzyme, Brian spearheaded the integration of the Bioverativ and Ablynx acquisitions, implemented financial modeling, and assembled franchise performance metrics for investor audiences. Earlier in his career, he held financial positions at Blue Cross Blue Shield of Massachusetts and KPMG. He earned a B.S. in accounting from Boston College.
Joining us as Jnana’s Vice President, Head of People & Culture, Danielle brings a wealth of knowledge and experience, having held roles of increasing responsibility across multiple human resources domains and a diverse set of industries. Prior to Jnana, Danielle held senior business partner roles at bluebird bio, supporting Pharmaceutical Sciences, Clinical Development, Regulatory and Medical Affairs, and built a centralized People Operations capability to support the organization’s rapid growth. She is a Master’s-level Organizational Development practitioner with expertise in organizational assessment and design, leadership development, and talent management. She leads with an unwavering dedication to the employee experience and focus on building foundational operations that allow businesses to scale effectively. Danielle holds a Bachelor’s degree in Psychology and Education from the University of Massachusetts Amherst and a Master’s degree in Organizational Psychology from William James College.