Immunologist (Principal Scientist Level)

Jnana Therapeutics is an exciting new startup focused on drugging the SLC family of metabolite transporters using a novel drug discovery platform. The company is focused on gut and immunometabolism, as well as lysosomal and mitochondrial function – important disease pathways where SLC transporters provide novel targets for inflammatory disorders, immuno-oncology, and neurological diseases.

At Jnana, we are passionate about leaving a legacy of healthy people, who as a result of breakthrough medicines lead transformed lives. We are building a company committed to innovative science, rigorous drug development, and a constant appreciation for the privilege to serve society by developing medicines. A bold team empowered to perform beyond traditional roles is at the center of all we do. We are seeking individuals who are inspired by this vision.

Role:

The successful candidate will have a deep knowledge of immunology and significant experience with cellular assays in immune cells, with a particular focus on innate immunity.  This role requires a self-starter with a Pharma or Biotech track record working and leading projects focused on macrophage or dendritic cell biology in autoimmune or inflammatory diseases, or immuno-oncology.  Knowledge of and experience in immunometabolism or disease pathways involved in inflammatory bowel disease would be especially useful.

Responsibilities: 

  • Responsibility for the development and validation of in vitro and ex-vivo immunoassays to evaluate innate immune cell function

  • Ability to generate and experimentally validate potential target hypotheses, with a deep mechanistic understanding of the target in disease pathways of interest

  • Presentation of results to the team, leadership, and Board members regularly with full transparency

  • Using excellent scientific and personal communication skills to work cross-functionally internally and externally with collaborators

  • Deep knowledge of the scientific literature, attendance at scientific conferences, and application of external insights to internal drug discovery programs

Qualifications and Skills: 

  • Ph.D. in Immunology with 7+ years of drug discovery Industry experience

  • Expertise with innate immune cell biology and functional assays, particularly macrophage and/or dendritic cell biology

  • Proficiency with immune cell assay technologies including flow cytometry, FACS analysis, and screens involving small molecules and/or genetic perturbations (e.g. CRISPR)

  • Collaborative researcher with strong teamworking skills

  • Desire to contribute insights outside of core expertise

  • Ability to adapt to frequent change and thrive in a dynamic and entrepreneurial early-stage environment

Marissa Picerno