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Senior Scientist/Principal Scientist (Computational Chemistry, Modeling)

Jnana Therapeutics is a biotechnology company focused on modulating cellular metabolism by opening the solute carrier (SLC) family of metabolite transporters as a target class to develop transformational therapeutics. Jnana uses RAPID, its proprietary, cell-based drug discovery platform to systematically target SLC transporters and develop best-in-class therapies to treat a wide range of diseases, including immune-mediated, neurological and metabolite-dependent diseases. Headquartered in Boston, Jnana is founded by world-renowned scientists and backed by leading life science investors. For more information, please visit www.jnanatx.com and follow us on Twitter and on LinkedIn.

POSITION DESCRIPTION

Jnana Therapeutics is seeking an enthusiastic and highly motivated computational chemist to support our internal chemistry group focused on SLC drug discovery programs. Through small molecule screening using our novel and proprietary RAPID platform, and a range of cell-based assays, our research aims to expand our understanding of SLC transporter biology and ultimately discover drugs modulating these proteins. Prior drug discovery, program experience necessary. Strong commitment and good work ethic are essential. Level can be flexible based on experience.

RESPONSIBILITIES

  • Help to drive medicinal chemistry design efforts with modern computational and modeling approaches through an understanding of the SAR, ADME properties and target biology
  • Champion emerging opportunities in ligand-based (pharmacophore modeling, shape-based expansion) and structure-based design (homology modeling, virtual screening).
  • Develop hypotheses of the mechanism of action and binding modes of lead compounds based on a deep understanding of current structural biology and homology models

QUALIFICATIONS

Required skills:

  • Knowledge and experience using modern structure-based and ligand-based methods with practical hands-on experience using those methods to drive small molecule drug design.
  • Experience with cheminformatics analyses such as nearest neighbor searches, R-Group deconvolution, and screening informatics
  • Experience with molecular modeling workflows such as conformational analysis, docking, and binding site assessment.
  • Experience building interactive visualization dashboards
  • Experience with molecular modeling workflows such as conformational analysis, docking, and binding site assessment.
  • This position requires a PhD in computational chemistry, with Postdoc or industry experience.
  • The successful candidate must be highly organized, detailed-oriented with excellent communication skills.

To apply, please email [email protected] or fill out the form directly through our website.

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