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Senior Principal Scientist/Associate Director (Preclinical Development)

Jnana Therapeutics is a biotechnology company utilizing a next generation chemoproteomic platform to address well-validated but hard-to-drug targets, including the solute carrier (SLC) family of metabolite transporters. Jnana is focused on developing best-in-class therapies to treat a wide range of diseases, including immune-mediated, neurological and metabolite-dependent diseases. Headquartered in Boston, Jnana is founded by world-renowned scientists and backed by leading life science investors. For more information, please visit and follow us on Twitter and on LinkedIn.


Jnana is seeking a highly skilled and motivated DMPK (drug metabolism and pharmacokinetics)  Senior Principal Scientist or Associate Director to join our team. The primary responsibilities for this position will be to design and oversee preclinical DMPK studies to progress our internal programs. Prior drug discovery and program experience is necessary, with a proven track record successfully advancing Discovery programs from target validation to Development Candidate and beyond. The right candidate will have a demonstrated ability to develop novel biology and chemical matter using a complement of in silico, in vitro, and in vivo studies to optimize drug-like properties, navigate drug liabilities, and build robust translational data packages. Experience designing and interpreting PK and PD in vivo studies, and fluency in predicting human PK parameters and efficacious dose-to-man based on nonclinical PK/PD data is required. Level can be flexible based on experience.


  • Design and execute in vitro and vivo studies to optimize the pharmacokinetics (PK), pharmacodynamics, absorption, metabolism, distribution, excretion and toxicity (ADMET) for novel SLC therapeutics
  • Responsible for the analysis, interpretation, integration, and reporting of DMPK data to characterize PK, efficacy and safety
  • Collaborate within multidisciplinary project teams to represent DMPK as a subject matter expert
  • Develop and implement DMPK strategies and project screening funnels that meet program goals by effectively leveraging and managing a global network of CROs
  • Design and implement fit-for-purpose biomarker strategies in support of a translational plan
  • Skilled in the use of modeling and simulation of in vitro and in vivo pharmacokinetic and pharmacodynamic data in support of human dose projections
  • Experienced developing novel in vivo and in vitro models to solve challenging ADMET and pharmacology issues of drug candidates.
  • Strategically prioritize programs with respect to opportunity, risk and resource bandwidth; ability to operate across scientific disciplines on multiple projects
  • Effectively communicate with the internal stakeholders regarding the project advancement and study plan, assay needs, method transfer and adoption, study progress updates, and DMPK bioanalytical deliverables. Plan study activities to meet the established timelines. Prioritize and re-prioritize activities as needed to deal with unanticipated, urgent and long term requests.
  • Author high quality regulatory documents including study reports, IB, IND, and CTA filings


  • Ph.D. in pharmacology, chemistry, biochemistry or related field with a minimum of 5-8 years of relevant industry experience supporting drug discovery programs.
  • Excellent technical expertise with a wide scope of ADMET and in life PK, PD, efficacy and safety studies.
  • Ability to solve complex scientific problems and to work equally effectively as a leader with external partners, or as a member within a matrixed, team environment.
  • Well organized with excellent inter-personal skills and oral and written communication capabilities for working in a dynamic team environment and mentoring junior scientists with collaborative mindsets.
  • Ability to communicate effectively with excellent internal and external communication and presentations skills.

To apply, please email [email protected] or fill out the form directly through our website.


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