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Principal Scientist/Senior Principal Scientist (Medicinal Chemistry)

Jnana Therapeutics is a biotechnology company focused on modulating cellular metabolism by opening the solute carrier (SLC) family of metabolite transporters as a target class to develop transformational therapeutics. Jnana uses RAPID, its proprietary, cell-based drug discovery platform to systematically target SLC transporters and develop best-in-class therapies to treat a wide range of diseases, including immune-mediated, neurological, and metabolite-dependent diseases. Headquartered in Boston, Jnana is founded by world-renowned scientists and backed by leading life science investors. For more information, please visit and follow us on Twitter and on LinkedIn.


Jnana Therapeutics is seeking an enthusiastic and highly motivated medicinal chemist to support our internal chemistry group focused on SLC drug discovery programs. Through small molecule screening using our novel and proprietary RAPID platform, and a range of cell-based assays, our research aims to expand our understanding of SLC transporter biology and ultimately discover drugs modulating these proteins. Prior drug discovery, program experience necessary. Strong commitment and good work ethic are essential. Level can be flexible based on experience.


  • Provide medicinal chemistry expertise to drive programs from hit generation to clinical candidate selection using state of the art design principles and strategies.
  • Utilize synthetic expertise to design and execute synthesis of target molecules.
  • Work closely with external chemistry CRO teams to synthesize and screen target molecules
  • Work collaboratively across scientific disciplines on multiple projects.
  • Proactively engage in brainstorming and the generation of new ideas across projects.
  • Assist in preparing patent applications and publications.
  • Maintain a safe and productive laboratory environment.
  • Help to build and expand an innovative platform for drug discovery.


  • Ph.D. and post-doctoral experience in Organic Chemistry with >5 years of industry experience as a medicinal chemist.
  • Preferred experience in leading hit-to-lead or LO programs and working directly with CRO chemistry.
  • Highly organized, detailed-oriented with excellent communication skills.


To apply, please email [email protected] or fill out the form directly through our website.


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