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Principal Scientist/Senior Principal Scientist (Cheminformatics)

Jnana Therapeutics is a biotechnology company focused on modulating cellular metabolism by opening the solute carrier (SLC) family of metabolite transporters as a target class to develop transformational therapeutics. Jnana uses RAPID, its proprietary, cell-based drug discovery platform to systematically target SLC transporters and develop best-in-class therapies to treat a wide range of diseases, including immune-mediated, neurological and metabolite-dependent diseases. Headquartered in Boston, Jnana is founded by world-renowned scientists and backed by leading life science investors. For more information, please visit www.jnanatx.com and follow us on Twitter and on LinkedIn.

POSITION DESCRIPTION

Jnana Therapeutics is seeking an enthusiastic and highly motivated computational chemist to support our internal chemistry group focused on SLC drug discovery programs. Through small molecule screening using our novel and proprietary RAPID platform, and a range of cell-based assays, our research aims to expand our understanding of SLC transporter biology and ultimately discover drugs modulating these proteins. Prior drug discovery, program experience necessary. Strong commitment and good work ethic are essential. Level can be flexible based on experience.

RESPONSIBILITIES

  • Accountable for all data workflows and data visualization within Jnana, including high-throughput screens and project screening data
  • Drive the development and implementation of new software tools and IT strategy to support data workflows for high-throughput screening, data capture, and virtual screening
  • Generate workflows to enable hit expansion and scaffold hopping from lead series

QUALIFICATIONS

Required skills:

  • Ability to perform complex data integration, analysis, and visualization to drive project team decisions
  • Experience in analyzing HTS data and providing expert opinion on the screening performance, hit-rate and hit quality.
  • Experience with cheminformatics analyses such as nearest neighbor searches, R-Group deconvolution, screening informatics
  • Experience building interactive visualization dashboards (e.g., Spotfire, Shiny web apps)
  • Experience with visual and dataflow programming (e.g., Pipeline Pilot, Knime)
  • Experience using cheminformatics and/or computational chemistry to drive drug discovery programs

Additional/Preferred skills:

  • This position requires a PhD in cheminformatics, computational chemistry, computer and information sciences, or related field, or PhD in Biology, Chemistry, or Chemical Biology with Postdoc and industry experience.
  • The successful candidate must be highly organized, detailed-oriented with excellent communication skills.

To apply, please email [email protected] or fill out the form directly through our website.

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