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Molecular Pharmacologist (Senior/Principal Scientist Level)

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Jnana Therapeutics is an exciting startup focused on modulating the SLC family of metabolite transporters in key disease pathways using a novel drug discovery platform. The company is focused on inflammatory bowel diseases, disorders of immunometabolism, and neurological disorders – areas where we believe drugging SLC transporters will provide effective medicines for diseases of high unmet need.

ROLE:

We are seeking a passionate scientist with a background in molecular pharmacology with a desire to unravel the details of interaction between small molecules and their targets. You will be an integral member of a disease/project team, focused on identifying and characterizing SLCs that regulate key metabolic pathways. You would in turn be involved with the characterization of small molecules modulators of SLC function from the level of probe molecules through to advancing drug discovery programs at the hit generation and lead optimization stages and beyond.

We value scientific rigor and intensity, but we are equally committed to building a fun and collaborative team.

RESPONSIBILITIES:

  • Apply state of the art pharmacology to understand the nature of the interaction and functional effect of small molecules on SLCs and other targets of interest.
  • Ability to generate and experimentally validate potential target hypotheses, with a deep mechanistic understanding of the target in disease pathways of interest. Focus on the use of pharmacological probes to achieve this. This could involve a range of assay types and end-points.
  • Presentation of results to the team, leadership, and Board members regularly with full transparency
  • Using excellent scientific and personal communication skills to work cross-functionally internally and externally with collaborators
  • Deep knowledge of the scientific literature, attendance at scientific conferences, and application of external insights to internal drug discovery programs

QUALIFICATIONS AND SKILLS:

  • PhD and 3+ years of postdoc experience; industry experience is desirable but not necessary.
  • A clear track record in molecular pharmacology and assay development– and the application of key principles to understand small molecule pharmacological activity.
  • Experience in gut biology, immunology or neuroscience is preferable but not essential.
  • A strong publication record.
  • Creative and collaborative researcher with strong team working skills and ability to thrive in a dynamic and entrepreneurial early-stage environment. Need to have urgency to translate data into approaches for new medicines.

To apply, please email jobs@jnanatx.com or fill out the form directly through our website.